Role of CD4 + T cells in the pathogenesis of Henoch-Schonlein purpura
10.3760/cma.j.issn.1673-4408.2021.04.003
- VernacularTitle:CD4 +T细胞亚群在过敏性紫癜发病机制中的作用
- Author:
Tong WEI
;
Xiaoxue MA
;
Hong JIANG
- From:
International Journal of Pediatrics
2021;48(4):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-Sch?nlein purpura(HSP)is an IgA-associated leukocytoclastic small-vessel vasculitis, commonly occurred in children.Recent studies have shown that its pathogenesis is closely related to the disturbance of humoral immune response mediated by B cells.CD4 + T cells have the function of help B cells.Each subgroup of CD4 + T cells has unique functions of promoting or regulating immune inflammatory response.There are abnormal changes in the proportion of CD4 + T cells subsets in HSP patients, including the imbalance of Th1/Th2, increasing numbers of Th17 and Tfh cells, together with decreasing Treg cell numbers.The changes are closely related to the occurrence, development and the clinical phenotype of HSP.It is suggested that the detection of CD4 + T cells plays critical roles in guiding the evaluation of HSP, and is expected to provide a new idea for the clinical diagnosis and individualized treatment of HSP.
