Invasive infections related to anti-TNF-α therapy in pediatric inflammatory bowel disease
10.3760/cma.j.issn.1673-4408.2021.04.002
- VernacularTitle:炎症性肠病患儿抗TNF-α治疗过程中的侵袭性感染
- Author:
Lu ZHENG
;
Yizhong WANG
;
Xiaolu LI
;
Ting ZHANG
- From:
International Journal of Pediatrics
2021;48(4):222-225
- CountryChina
- Language:Chinese
-
Abstract:
Anti-tumor necrosis factor-α(anti-TNF-α)agents have been widely used in the treatment of inflammatory bowel disease(IBD)in children.Anti-TNF-α therapy can effectively induce and maintain disease remission, promote intestinal mucosal healing, and prevent long-term end-stage organ damage and growth retardation in pediatric IBD patient.Anti-TNF-α agents can significantly impair the human immune function, which may increase the infection risk of IBD children, including the infection of bacteria, viruses, fungi and mycobacteria.This study summarizes the current published literature regarding infections in pediatric patients with IBD receiving anti-TNF-α therapies, which can help to improve the cognition of pediatric medical staff on opportunistic infection of pediatric IBD patients following anti-TNF-α treatment.
