Advances in the treatment of West syndrome with hormonal therapies
10.3760/cma.j.issn.1673-4408.2021.03.010
- VernacularTitle:激素相关方案治疗West综合征的研究进展
- Author:
Liu YANG
;
Jianxiang LIAO
- From:
International Journal of Pediatrics
2021;48(3):186-190
- CountryChina
- Language:Chinese
-
Abstract:
West syndrome is one of the most common refractory epileptic syndromes with onsets mostly in infancy.The prognosis is generally poor.The morbidity rate reported in the literature is 0.2‰ to 0.5‰.Hormonal therapies(Adrenocorticotropic hormone and glucocorticosteroid)are recommended as preferred treatment options for West syndrome.It can effectively control spasms, ameliorate recognition impairment, and improve developmental outcomes.The incidence of side effects after hormonal therapy are high, and irritation, hypertension and infection are frequently reported.In this paper, advances in therapeutic mechanism, usage and dosage, short-term effectiveness, long-term effectiveness, prognosis and adverse effects of hormonal therapies are reviewed.
