Progress in diagnosis and treatment of Epstein-Barr virus infection-related lymphoproliferative diseases in children
10.3760/cma.j.issn.1673-4408.2021.03.002
- VernacularTitle:儿童EB病毒感染相关淋巴增生性疾病的诊治进展
- Author:
Xiaopeng MA
;
Yongjun FANG
- From:
International Journal of Pediatrics
2021;48(3):150-154
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-Barr(EB)virus is the first carcinogenic virus discovered in 1964.EBV infection is common in pediatrics and most of the infected children are asymptomatic.When the immune function of children becomes low or deficient, EBV may cause a series of benign or malignant lymphoproliferative diseases, such as infectious mononucleosis, chronic active EBV infection, hemophagocytic lymphohistiocytosis, post-transplant lymphoproliferative disorders, X-linked lymphoproliferative syndrome and so on.Most of these diseases have complex pathogenesis, diverse clinical manifestations, poor prognosis and high mortality.The only effective treatment is allogeneic hematopoietic stem cell transplantation.
