The role of interferon-γ and its antibody antagonists in hemophagocytic lymphohistiocytosis
10.3760/cma.j.issn.1673-4408.2021.03.001
- VernacularTitle:γ干扰素及其抗体拮抗剂在噬血细胞性淋巴组织细胞增生症中的研究进展
- Author:
Fenfen CHENG
;
Rui ZHANG
;
Tianyou WANG
- From:
International Journal of Pediatrics
2021;48(3):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Hemophagocytic lymphohistiocytosis(HLH), also known as hemophagocytic syndrome(HPS), is a hyperinflammatory syndrome caused by multiple etiologies.Interferon-γ(IFN-γ)has been reported to play a key role in the pathogenesis of HLH, and antibody against IFN-γ(emapalumab)can be used to treat HLH.Here, the findings on the role of IFN-γ in pathogenesis and emapalumab in treatment of HLH are reviewed respectively.
