Diagnosis and treatment of myelin oligodendrocyte glycoprotein antibody related inflammatory demyelinating diseases in children
10.3760/cma.j.issn.1673-4408.2021.02.013
- VernacularTitle:儿童髓鞘少突胶质细胞糖蛋白抗体相关炎性脱髓鞘疾病诊治进展
- Author:
Mingping LAN
;
Wenguang HU
- From:
International Journal of Pediatrics
2021;48(2):127-131
- CountryChina
- Language:Chinese
-
Abstract:
Myelin oligodendrocyte glycoprotein(MOG)is expressed in oligodendrocytes of the mammalian central nervous system, which is located on the surface and an important component of the myelin sheath.MOG antibody related inflammatory demyelinating disease is a hot topic in the field of neurology in recent years, and its clinical phenotype spectrum varies.Currently, cell-based assay(CBA)is recommended to detect MOG antibodies in peripheral blood.Due to the complexity and diversity of the clinical manifestations, and different manifestations in different age groups, it is difficult to make the clinical diagnosis.The exact pathogenesis is still unclear, and the therapeutic options and long-term prognosis remain controversial.In this article, the pathogenesis, clinical manifestations, treatment options and clinical prognosis of MOG antibody related inflammatory demyelinating diseases will be reviewed.
