CD4 + T cell differentiation in rheumatoid arthritis
10.3760/cma.j.issn.1673-4408.2021.02.014
- VernacularTitle:CD4 ＋T细胞分化在类风湿关节炎中的研究进展
- Author:
Yan XU
;
Zhidan FAN
;
Haiguo YU
- From:
International Journal of Pediatrics
2021;48(2):132-136
- CountryChina
- Language:Chinese
-
Abstract:
The dysfunction of T cells, especially the interaction of antigen presenting cells and CD4 + T cells, leads to abnormal activation of CD4 + T cells and the initiation of adaptive immune response.Dysfunction of the immune system plays an important role in the pathogenesis of rheumatoid arthritis.It is always considered as the central link of synovial continuous inflammation, articular cartilage and bone destruction in rheumatoid arthritis patients.Exploring CD4 + T cell differentiation and cell subsets provides a new perspective for understanding of arthritis and helps to identify new drug targets.
