Research progress of long non-coding RNA in congenital heart disease
10.3760/cma.j.issn.1673-4408.2021.02.001
- VernacularTitle:先天性心脏病中长链非编码RNA研究进展
- Author:
Ting LI
;
Wei SHENG
;
Guoying HUANG
- From:
International Journal of Pediatrics
2021;48(2):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Congenital heart disease is one of the most common birth defects, which is the main cause of death in children.Cardiovascular development is a complex process involving multiple genes, signaling pathways and regulatory factors.According to the sequencing of human genome and encode project, more than 80% of the genes in the genome are transcribed, but only 3% of these transcripts correspond to protein-encoding RNA.It is pointed out that non-coding RNA is as important or even more important as encoding RNA.More and more evidences show that not only encoding genes are involved in the regulation of cardiovascular development, but also protein non-coding genes play an important role in the development of heart.This review will summarize the biological characteristic and function of long noncoding RNAs, and introduce the role of some representative lncRNA in heart development and congenital heart disease.
