Immune injury mechanism and umbilical cord blood therapy in type 1 diabetes mellitus
10.3760/cma.j.issn.1673-4408.2021.02.011
- VernacularTitle:1型糖尿病免疫损伤机制及脐血治疗新进展
- Author:
Qingfang SONG
;
Liyang LIANG
- From:
International Journal of Pediatrics
2021;48(2):117-121
- CountryChina
- Language:Chinese
-
Abstract:
As one of the common endocrine diseases in children, the incidence of type 1 diabetes mellitus(T1DM)is increasing year by year.T1DM is an autoimmune disease.It is generally believed that the pathogenesis of T1DM is that the immune disorder of genetically susceptible individuals under the action of environmental factors causes immune damage, leading to islet inflammation and the production of autoantibodies, and the destruction of β cells of the islet, leading to insufficient insulin secretion to absolute deficiency.Although there is no effective radical cure for T1DM at present, more and more research on stem cell therapy has been conducted.Umbilical cord blood, as an important source of stem cells, is expected to make the radical cure of T1DM possible in the future.In this paper, the mechanism of immune injury in T1DM and the progress of umbilical cord blood stem cell therapy are reviewed.
