Pathogenesis and therapy in sepsis-induced cardiomyopathy
10.3760/cma.j.issn.1673-4408.2021.02.006
- VernacularTitle:脓毒性心肌病病理生理机制及治疗研究进展
- Author:
Weilan NA
;
Huili SHEN
;
Dong QU
- From:
International Journal of Pediatrics
2021;48(2):95-98
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-induced cardiomyopathy(SICM)is a reversible cardiac insufficiency in the early stage of sepsis, and mainly manifests as left ventricular dilation, decreased ejection fraction, and recovery within 7~10 days.Although it is reversible, the incidence and mortality in sepsis are high.The specific mechanism is still unclear.Inflammatory reaction, mitochondrial dysfunction, apoptosis and other pathophysiological processes play an important role.Its process is complex and involves the interaction between organism and pathogen.The management of SICM is still based on the etiologic treatment of septic shock guided by hemodynamic monitoring and tissue perfusion, with cardio-protective therapy and specific measures.This review summarizes the literatures on the mechanisms and treatments of SICM.
