Progress of single-cell sequencing in multiple myeloma
10.3760/cma.j.cn115356-20201118-00280
- VernacularTitle:单细胞测序技术在多发性骨髓瘤中的研究进展
- Author:
Jiamei JI
;
Xiaoyan QU
- From:
Journal of Leukemia & Lymphoma
2021;30(4):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma (MM) is a malignant hematological disorder caused by the abnormal proliferation of monoclonal plasma cells. Traditional high-throughput cell sequencing reflects the heterogeneity of cell population, while it ignores the genetic information in single-cell. The development of single-cell sequencing has enabled the access to cell-to-cell variation in tumor and microenvironment of bone marrow, providing a deep understanding of the pathogenic mechanisms of MM and guidance for clinical treatment. This paper reviews the latest progress of single-cell sequencing and its application in disease pathogenesis, monitoring of disease progression, immunotherapy and therapeutic responses of MM.
