Application of the new generation cytogenetics technology in structural variation of leukemia genome

VernacularTitle:新一代细胞遗传学技术在白血病基因组结构变异分析中的应用
Author: Yang ZHANG ; Tong WANG ; Fang WANG ; Hongxing LIU
From: Journal of Leukemia & Lymphoma 2021;30(4):197-200
CountryChina
Language:Chinese
Abstract: Structural variation (SV) of the genome is a group of critical genetic abnormalities in hematological tumors. The currently commonly-used cytogenetics and gene testing techniques have significant limitations in the detection of SV. Genome optical mapping technology provides a powerful tool for analyzing SV with ultra-long fragments, high resolution, automation, high throughput and genome-wide range. It is also known as the next-generation cytogenetics (NGC) technology. In recent years, there have been research reports on the use of NGC for the analysis of SV of leukemia genome. The related research progress is now introduced in conjunction with the reports at the 62nd American Society of Hematology Annual Meeting.