Progress of molecular pathological typing of diffuse large B-cell lymphoma

VernacularTitle:弥漫大B细胞淋巴瘤分子病理分型研究进展
Author: Qiang HOU ; Yuye SHI ; Wei SANG ; Chunling WANG
From: Journal of Leukemia & Lymphoma 2021;30(2):125-128
CountryChina
Language:Chinese
Abstract: Diffuse large B-cell lymphoma (DLBCL) is characterized by heterogeneity with respect to morphology, immune phenotype, molecular pathogenesis, clinical presentation and prognosis. With the development of genome and transcriptome sequencing, DLBCL was classified as four subtypes (EZB, BN2, MCD, and N1) or five subtypes (C1-C5). The new molecular pathological typing has a deeper understanding of DLBCL from the levels of genes and molecules which makes the judgment of prognosis more accurate and specific, and it is conducive to the clinical screening of more accurate targeted therapy.