Research progress on the regulatory mechanism of estrogen in periodontal ligament cells repair and the reconstruction of periodontal tissue
10.12016/j.issn.2096-1456.2021.11.011
- Author:
LI Qi
1
;
WANG He
2
;
HUANG Zijun
1
;
HAN Qianqian
3
Author Information
1. Stomatological College of Zhaoqing Medical College, National Application Technology Collaborative Innovation Center of Primary Medical Service
2. Department of Endodontics Periodontal, Stomatological Hospital, Southern Medical University
3. Department of Periodontal, Stomatological Hospital, Southern Medical University
- Publication Type:Review
- Keywords:
estrogen;
periodontal ligament stem cells;
periodontal ligament fibroblasts;
cementoblasts;
osteoblasts;
osteoclasts;
bone mesenchymal stem cells;
collagen I;
osteopontin;
bone sialoprotein;
osteocalcin
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(11):787-792
- CountryChina
- Language:Chinese
-
Abstract:
Periodontium regeneration and repair is a controversial and difficult point in the treatment of periodontosis. The proliferation, differentiation, migration and adhesion of periodontal ligament cells and the dynamic relationship between periodontal ligament cells and their extracellular matrix proteins are the basis of periodontium morphological reconstruction, functional maintenance and tissue repair. This article reviews the mechanism of estrogen-regulated periodontal membrane fine repair and periodontal tissue reconstruction to provide the basis for follow-up research on the treatment of periodontitis and the promotion of periodontal tissue repair and reconstruction by exogenous estrogen-mediated periodontal membranes. Under the regulation of certain concentrations of estrogen, the proliferation and differentiation ability of periodontal ligament stem cells (PDLSCs) and bone mesenchymal stem cells (BMSCs) to other periodontal ligament cells were enhanced. At the same time, PDLSCs, BMSCs, human periodontal ligament fibroblasts (HPLFSs), osteoblasts and cementoblasts synthesized and secreted collagen I (COLI), osteopontin (OPN), bone sialoprotein (BSP) and osteocalcin (OCN) into the extracellular matrix. They interact with fibronectin (FN) and cementum attachment protein (CAP) in the extracellular matrix to form a variety of chain complexes and regulate each other, thus promoting the growth, migration, adhesion and fibrosis of periodontal ligament cells, repairing the collagen fiber skeleton of the periodontal ligament and adhering the two ends to the new cementum and the inherent alveolar bone.
- Full text:雌激素对牙周膜细胞修复重建牙周组织调节机制的研究进展.pdf
