One Case of Hand-foot Syndrome Recurrence Induced by Sequential Paclitaxel Liposome for Injection with Doxorubicin Hydrochloride Liposome Injection and Literature Review
- VernacularTitle:注射用紫杉醇脂质体序贯盐酸多柔比星脂质体注射液致手足综合征复发1例及文献复习
- Author:
Fei HE
1
;
Yikun KANG
2
;
Fang ZHAO
2
;
Xin LIANG
1
;
Pin ZHANG
2
Author Information
1. Dept. of Pharmacy，National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital，Peking Union Medical College，Chinese Academy of Medical Sciences，Beijing 100021，China
2. Dept. of Internal Medicine，National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital，Peking Union Medical College，Chinese Academy of Medical Sciences，Beijing 100021，China
- Publication Type:Journal Article
- Keywords:
Doxorubicin liposome;
Paclitaxel liposome;
Hand-food syndrome;
ADR;
Recurrence;
Clinical pharmacists
- From:
China Pharmacy
2021;32(14):1776-1779
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To investigate the role of clinical pharmacists in the diagnosis and treatment of liposome-induced hand-food syndrome （HFS），and to provide reference for rational use of liposome preparation in clinic. METHODS ：One case of elderly female patient with breast cancer ，admitted to our hospital suffered from HFS （grade 2）after treated with Doxorubicin hydrochloride liposome ；after successful therapy ，the patient had skin symptoms （grade 3）again due to Paclitaxel liposome ，and clinical pharmacist judged the recurrence of HFS. For symptomatic treatment ，stopping the treatment and external use of hormone was suggested ，and whole-process pharmaceutical care was provided. The pathogenesis ，differential diagnosis ，risk factors and therapeutic drugs of HFS were summarized based on literature review and 2 case reports in the database. RESULTS ：The physicians adopted the suggestion of clinical pharmacists ；the patient ’s symptoms improved significantly on the third day and disappeared after 1 week. Combined with literature analysis and 2 case reports ，doxorubicin liposome metabolized more slowly than non liposomes in palms and soles of feet ，resulting in accumulation of doxorubicin in sweat duct and stratum corneum ，aggravating skin damage and leading to HFS. Sequential paclitaxel in liposome form may also lead to the accumulation in eccrine duct ，further caused skin damage and induced HFS. CONCLUSIONS ：Clinical pharmacists actively participate in the diagnosis and treatment of ADR ， which is conducive to the rehabilitation of patients. At same time ，combination or sequential of Paclitaxel liposome with PLD should be avoided ，as it can lead to ADR as HFS.
