Optimization of Inclusion Technology of Volatile Oil from Ganmao Qingre Granules
- VernacularTitle:感冒清热颗粒挥发油包合工艺的优化
- Author:
Dongge ZHANG
1
,
2
;
Fengxia WANG
2
;
Yujie YANG
1
;
Chunmin WANG
2
;
Baoxin CHEN
2
;
Xinyu WU
2
Author Information
1. Institute of TCM，Chengde Medical College，Hebei Chengde 067000，China
2. Hebei Technology Innovation Center of TCM New Excipient Engineering，Jingfukang Pharmaceutical Group Co.，Ltd.，Hebei Chengde 067000，China
- Publication Type:Journal Article
- Keywords:
Quality by design;
Ganmao qingre granules;
Volatile oil;
Inclusion technology;
Box-Burman response surface
- From:
China Pharmacy
2021;32(14):1734-1740
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To optimize the inclusion technology of volatile oil from Ganmao qingre granules. METHODS ： Guided by the concept of “quality by design ”，taking volatile oil inclusion rate and inclusion complex yield as key quality attribute，comprehensive score of above two indexes after weighting as response value ，inclusion temperature ，inclusion time ，the ratio of β-CD to volatile oil as key technology parameters ，Box-Burman response surface design was adopted to establish the design space of key technology parameters and key quality attributes. The design space was optimized and verified by 95％ confidence interval. The stability of inclusion complex was investigated preliminarily. RESULTS ：The optimal design space ，i. e. the optimal technology parameters rang ，included inclusion temperature 35-40 ℃，inclusion time 1.8-2.0 h，the ratio of β-CD to volatile oil 9.5∶1- 10∶1（g/mL）. The results of 3 validation tests showed that the volatile oil inclusion rates were all over 62％，the yields of inclusion complex were all over 75％，and the comprehensive scores were all over 80 point. The results of preliminary stability showed that the inclusion rate of volatile oil ，the yield of inclusion complex and the comprehensive score did not change significantly. The difference in evaluation indicators within 7 days was within 5％. CONCLUSIONS ：The optimized inclusion technology is feasible ， and the obtained inclusion complex is stable.
