Microbial transformation of Asiatic acid by Syncephalastrum racemosum CGMCC 3.2500
10.12206/j.issn.1006-0111.202012005
- VernacularTitle:总状共头霉CGMCC 3.2500对积雪草酸的生物转化
- Author:
Hui LI
1
;
Jing WANG
1
;
Shenyong GU
1
Author Information
1. Department of Pharmacy, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China.
- Keywords:
asiatic acid;
microbial transformation;
Syncephalastrum racemosum
- From:
Journal of Pharmaceutical Practice
2021;39(4):336-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective Asiatic acid is the main medicinal component of aursane pentacyclic triterpene and possessed various biological activities. In order to obtain better active Asiatic acid analogues, microbial transformation was used for structural modification. Methods Asiatic acid was biotransformed by Syncephalum racemosum CGMCC 3.2500. The structure of the compound was identified by high resolution electrospray ionization mass spectroscopy (HR-ESI-MS) and nuclear magnetic resonance spectroscopy (i.e., 1H NMR、13C NMR、1H-13C HSQC、1H-13C HMBC、1H-1H NOESY). Results The structure of the compound was determined as 2-oxo-3α, 15α, 23-trihydroxyurs-12-en-28-oic acid which was a new compound. Conclusion Syncephalum racemosum CGMCC 3.2500 can modify the structure of Asiatic acid and obtain Asiatic acid analogues.
