Cytotoxicity study on FC58, an indole-chalcone, against multi-drug resistant leukemia cells
10.12206/j.issn.1006-0111.202012008
- VernacularTitle:吲哚查尔酮衍生物FC58的抗白血病多药耐药活性研究
- Author:
Jiawei DAI
1
;
Saijian SHI
2
;
Aiwei SONG
3
;
Zhibin WANG
2
;
Chunlin ZHUANG
2
;
Chunnian XIA
1
Author Information
1. School of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
3. Montverde Academy Shanghai, Shanghai 201201, China.
- Keywords:
indole-chalcone;
anti-leukemia;
multi-drug resistance;
cytotoxicity;
tubulin
- From:
Journal of Pharmaceutical Practice
2021;39(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize and investigate cytotoxicity of an indole-chalcone derivative FC58. Methods The target compound was synthesized through the Aldol condensation with 1-(3,4,5-trimethoxyphenyl)ethan-1-one and 1H-indole-3-carbaldehyde. The Cell Titer-Blue method was used to determine in vitro cytotoxicity. The cell cycle experiment was performed to analyze the action characteristics of FC58. Results FC58 exhibited high cytotoxicity against various leukemia cells and resulted in G2/M phase arrest. It showed stronger drug resistant index than traditional tubulin inhibitors such as paclitaxel, vinblastine and doxorubicin. Conclusion FC58 represents a promising lead compound for multi-drug resistant leukemia.
