The synergistic effect of SARS-CoV-2 spike protein, angiotensin-converting enzyme 2 and protease on corona virus disease 2019
10.19428/j.cnki.sjpm.2021.20574
- VernacularTitle:刺突蛋白、血管紧张素转换酶2和蛋白酶在新型冠状病毒感染中的协同作用
- Author:
Yue ZHAO
1
;
Wen-bin LIU
;
Zi-shuai LI
;
Guang-wen CAO
Author Information
1. Department of Naval Epidemiology, Naval Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
SARS-CoV-2;
spike glycoprotein;
angiotensin-converting enzyme 2;
protease
- From:
Shanghai Journal of Preventive Medicine
2021;33(3):237-
- CountryChina
- Language:Chinese
-
Abstract:
The severe acute syndrome coronavirus 2(SARS-CoV-2)is responsible for the global pandemic of 2019 novel coronavirus disease(COVID-19). Understanding the pathogenic mechanisms of SARS-CoV-2 is of great significance to the prevention and control of the COVID-19 epidemic. The spike(S)protein of SARS-CoV-2 is a major target of protective immunity. The mutations of S protein impact the transmission and pathogenic capacity of SARS-CoV-2. In addition, angiotensin-converting enzyme 2(ACE2)is the receptor of SARS-CoV-2 S protein and mediates viral entry into target cells. The genetic polymorphisms of the ACE2 gene may lead to the difference of incidence of COVID-19 among different populations. Protease can promote the infection of SARS-Cov-2 by activating the S protein. This review summarized the current understanding of the function and genetic variants of S protein, ACE2, and the related proteases. The synergistic effect of these three molecules on the susceptibility of SARS-CoV-2 infection was further discussed.
