Application of serum antibody detection in the identification of transmission chain of COVID-19
10.19428/j.cnki.sjpm.2021.20213
- VernacularTitle:血清抗体检测在一起新型冠状病毒肺炎疫情传播链推断中的应用
- Author:
Han-wu ZHU
1
;
Jing LIU
;
De-biao HE
;
Hong ZHOU
;
Wen ZHENG
;
Liang ZHOU
;
Hui TAN
Author Information
1. Chenzhou Center for Disease Control and Prevention, Chenzhou, Hunan 423000, China
- Publication Type:Research Article
- Keywords:
COVID-19;
2019-nCoV;
transmission chain;
serum antibody;
inference
- From:
Shanghai Journal of Preventive Medicine
2021;33(3):192-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the transmission chain of COVID-19 by serum antibody detection, and to provide scientific evidence for the prevention and control of the epidemic. Methods Field epidemiological investigation was used to determine the COVID-19 cases and their close contacts. The 2019-nCoV nucleic acid in throat swabs and anal swabs were examined by RT-PCR. Serum specimens were collected for anti-2019-nCoV IgM antibody detection and combined IgM/IgG detection. Results Case A had no confirmed exposure to COVID-19. However, case C and D had dinner and lived together with case A; they reported contact history and dinner history with other confirmed COVID-19 cases(H, L). Case A tested positive for 2019-nCoV nucleic acid, whereas case C and D were negative. Moreover, case A and C were IgM antibody positive, while case D was negative. Case A, C and D were all positive for combined IgM/IgG. In addition, case D had clinical symptom, while case C did not. Conclusion Serum antibody detection can be used as an effective supplement to the inference of transmission chain of COVID-19, which may facilitate determining the source of infection and improving the evidence.
