The relationship between genetic factors and plasma lipids in Vietnamese living in rural areas
- Author:
Thu Nguyet Nghiem
;
Anh Do Van Nguyen
;
Khan Cong Nguyen
;
Mai Thi Tuyet Ta
;
Chuyen Van Nguyen
- Publication Type:Journal Article
- Keywords:
Genetic factors;
plasma lipids;
rural area
- MeSH:
Genetic factors;
plasma lipids;
rural area
- From:Journal of Preventive Medicine
2008;0(3):13-17
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Plasma lipids are affected not only by dietary intake and life style but also by genetic factor. Objective: To discover the relationship between plasma lipids and the presence of LPL S447X and PAF-AH V279F in the bodies of rural Vietnamese population. Subject and Method: One hundred and ninety three subjects were randomly selected from rural areas in Ho Chi Minh city. The presence of LPL S447X and PAF-AHV279F polymorphism was determined using an Invader assay, and the plasma lipid levels were measured by an enzymatic method. A profile regarding the dietary intake was also made for each subject. Result and Conclusion: The frequency of LPL 447SX/XX (12.2%) polymorphism, PAF-AH Val279Phe mutation allele frequency (5.4%) in the Vietnamese was closely similar to that of other Asian populations. LPL447X polymorphism was found to be significantly associated with a higher HDL-C level in comparison to LPL 447S. LPL S447X affects plasma HDL-C and TG concentration in Vietnamese rural population.
