Research progress on correlation between lncRNAs and pathogenesis of vascular diseases
10.11763/j.issn.2095-2619.2021.01.020
- Author:
Mao-sheng YAN
1
,
2
;
Sen-zhou FANG
;
Dan-ying ZHANG
1
,
2
;
Guo-yong XU
1
,
2
;
Xin-qi LIN
1
,
2
;
Hua YAN
1
,
2
Author Information
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatment
2. Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment Guangzhou, Guangdong 510300, China
- Publication Type:Journal Article
- Keywords:
Long noncoding RNAs;
Endothelial cells;
Vessel smooth muscle cell;
Angiogenesis;
Biomarker;
Hand-arm vibration disease;
Research progress
- From:
China Occupational Medicine
2021;48(01):103-106
- CountryChina
- Language:Chinese
-
Abstract:
Occupational hand-arm vibration diseases(HAVD) is a legitimate occupational disease in China, and the mechanism of its pathogenesis is vibration-induced vascular injury. Once HAVD occurs, it is difficult for the patients to recover and can cause great harm to workers exposed to hand-arm vibration. It is difficult to detect and evaluate the occurrence and progress of the disease at an early stage using existing technology, which is disadvantageous to the early prevention and treatment of the disease. Long noncoding RNAs(lncRNAs) play an important role in regulating the development, growth, and remodeling of blood vessels and other biological processes. This article reviews the role and mechanism of lncRNAs in vascular injury, and provides scientific theoretical basis for early diagnosis and treatment of HAVD.
