Research progress on the effect of TSG-6 secreted from mesenchymal stem cells in repairing tissue injury
10.11763/j.issn.2095-2619.2021.01.018
- Author:
Rui-hong FAN
1
;
Yong-shun HUANG
;
Na ZHAO
Author Information
1. School of Public Health, Sun Yat-sen University Guangzhou, Guangdong 510300, China
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Tumor necrosis factor α stimulated protein 6;
Inflammation;
Fibrosis;
Damage repair;
Research progress
- From:
China Occupational Medicine
2021;48(01):93-97
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells(MSCs) have functions such as immune regulation and tissue damage repair, but the specific mechanisms of their effects need to be further studied. Paracrine effect is an important mechanism for MSCs to achieve immune regulation, relieve inflammation and repair tissue damage. Tumor necrosis factor α(TNF-α) stimulated protein 6(TSG-6) is one of the paracrine factors of MSCs, which has significant inflammation inhibitory capability and tissue repair ability. It is an important cytokine of MSCs to exert their anti-inflammatory and anti-fibrotic effects. The MSCs can repair tissue damage in kidney, peritonea, skin, liver, lung, cornea, nervous system, and colon by secreting TSG-6. This powerful repair ability could be attributed to the ability of TSG-6 to inhibit the secretion of pro-inflammatory cytokines and pro-fibrogenic factors, such as TNF-α, interleukin(IL)-6, IL-1β and transforming growth factor-β1, thereby reducing the inflammatory response and fibrosis of the body.
