Effect of Hyperbilirubinemia on the Brainstem Auditory Evoked Response in Newborn Piglets.
- Author:
Chang Won CHOI
1
;
Jong Hee HWANG
;
Saem KANG
;
Jae Won SHIM
;
So Hee CHUNG
;
Sun Young KOH
;
Yun Sil CHANG
;
Won Soon PARK
Author Information
1. Department of Pediatrics, Samsung Seoul Hospital, College of Medicine, Sungkyunkwan University, Seoul, Korea. wspark@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Hyperbilirubinemia;
Brainstem auditory evoked response;
Piglet
- MeSH:
Bilirubin;
Brain Stem*;
Evoked Potentials, Auditory*;
Humans;
Hyperbilirubinemia*;
Infant, Newborn*;
Infusions, Intravenous
- From:Journal of the Korean Society of Neonatology
2003;10(2):248-253
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We sought to know the effect of hyperbilirubinemia on brainstem auditory evoked response in newborn piglets. METHODS: To achieve the concentration of bilirubin above 20 mg/dL, we injected a bolus of 50 mg/kg of bilirubin intravenously over 30 minutes, followed by 30-40 mg/kg/ hr of bilirubin continuous intravenous infusion to 10 newborn piglets. Brainstem auditory evoked responses were obtained from these piglets at baseline, 1 hour, 2 hours, 3 hours and 4 hours after the exposure to hyperbilirubinemia. RESULTS: The mean amplitude of wave V was 0.33+/-0.03 microV at baseline, 0.32+/-0.04 microV at 1 hour, 0.33+/-0.05 microV at 2 hours, 0.23+/-0.04 microV at 3 hours and 0.26+/-0.05 microV at 4 hours of experiment and began to decrease after 3 hours of the exposure to hyperbilirubinemia. The latency of wave III was 4.06+/-0.08 ms at baseline, 3.95+/-0.09 ms at 1 hour, 4.05+/-0.10 ms at 2 hours, 4.05+/-0.09 ms at 3 hours, 4.12+/-0.11 ms at 4 hours of experiment and began to increase after 1 hour of the exposure to hyperbilirubinemia. CONCLUSION: Hyperbilirubinemia decreased the amplitude of wave V and increased the latency of wave III of brainstem auditory evoked responses in newborn piglets.
