Correlation between endothelial microparticles and subacute 1,2-dichloroethane toxic encephalopathy
10.11763/j.issn.2095-2619.2020.04.016
- Author:
Hanwen HU
1
;
Tailing LIU
1
;
Yuqing YAN
1
;
Min TAN
1
;
Feng ZHU
1
;
Jianwu DAI
1
;
Zhibing HU
1
Author Information
1. Department of Neurology,Guangzhou 12th People's Hospital (Guangzhou Occupational Disease Prevention and Control Hospital) Guangzhou,Guangdong 510620,China
- Publication Type:Journal Article
- Keywords:
Endothelial microparticles;
1,2-Dichloroethane;
Toxic encephalopathy;
Correlation
- From:
China Occupational Medicine
2020;47(04):460-462
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the correlation between endothelial microparticles(EMPs) and subacute 1,2-dichloroethane(1,2-DCE) toxic encephalopathy. METHODS: A total of 24 patients with subacute 1,2-DCE toxic encephalopathy were selected as the case group, and 24 healthy individuals were selected as the control group using a convenient sampling method. Blood plasma was collected from the fasting venous blood of patients in these two groups, and the level of EMPs in the plasma was detected by flow cytometry. RESULTS: The levels of plasma EMPs of patients in the control group and the case group were(692.0±174.4) ×10~3/L and(839.8±155.8) ×10~3/L respectively. The levels of plasma EMPs in patients with mild, moderate and severe case subgroups were(691.6±101.9) ×10~3/L,(900.6±46.6) ×10~3/L and(1 026.8±69.8)×10~3/L respectively. The EMPs level of patients in the case group was higher than that of the control group(P<0.01). The level of EMPs in the moderate and severe case subgroups was higher than that of the control group and mild case subgroup(P<0.01). CONCLUSION: Endothelial injury was found in patients with subacute 1,2-DCE toxic encephalopathy and endothelial injury is related to the severity of poisoning.
