Detecting the aminopyridine compounds in workplace air by solvent eluting-gas chromatography
10.11763/j.issn.2095-2619.2020.01.016
- Author:
Weifeng RONG
1
,
2
;
Weijie LING
;
Geng ZHANG
;
Jiawen HU
1
,
2
;
Ruibo MENG
1
,
2
;
Banghua WU
1
,
2
Author Information
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatment
2. Guangdong Provincial Key Laboratory of Occupational Diseases Prevention and Treatment Guangzhou, Guangdong 510300, China
- Publication Type:Journal Article
- Keywords:
Workplace;
Air;
2-Aminopyridine;
3-Aminopyridine;
4-Aminopyridine;
Gas chromatography
- From:
China Occupational Medicine
2020;47(01):86-90
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a method for simultaneous detection of 2-aminopyridine, 3-aminopyridine and 4-aminopyridine in workplace air by solvent eluting-gas chromatography. METHODS: 2-aminopyridine, 3-Aminopyridine and 4-aminopyridine in workplace air were collected by glass fiber filter paper dipped with sulfuric acid solution, and eluted using sodium hydroxide solution. After that, the eluent was separated by capillary column, and finally detected using the nitrogen and phosphorus detector. RESULTS: The quantitative determination ranges of 2-aminopyridine, 3-aminopyridine and 4-aminopyridine were 0.30-800.00, 0.80-800.00 and 2.00-800.00 mg/L respectively, with the correlative coefficients greater than 0.999 9. The minimum detectable concentrations were 4.67, 8.00 and 40.00 μg/m~3 respectively, and the minimum quantification concentrations were 14.00, 28.00 and 133.33 μg/m~3(45.00 L sample, 3.00 mL eluent) respectively. The average elution efficiencies were 79.63%-98.61%, 83.80%-101.42% and 81.60%-100.29% respectively. The within-run relative standard deviations(RSD) were 1.13%-3.65%, 1.47%-4.00% and 1.94%-5.15% respectively, and the between-run RSD were 1.77%-5.30%, 2.06%-4.65% and 2.59%-6.46% respectively. Samples were stable at room temperature for at least 14 days. CONCLUSION: This method is appropriate to be applied for simultaneous detection of 2-aminopyridine, 3-aminopyridine and 4-aminopyridine in workplace air.
