Clinical analysis on 2 cases of acute thallium poisoning with combined treatment using blood purification and sodium dimercaptosulfonate
10.11763/j.issn.2095-2619.2018.03.016
- Author:
Juan YUAN
1
;
Yan LAI
1
;
Lei HUANG
1
;
Fangkun TANG
1
;
Yunhua ZHANG
1
;
Lun HONG
1
;
Chuntao HUANG
1
Author Information
1. Poisoning Department of Hunan Provincial Institute for Occupational Disease Prevention and Treatments Changsha,Hunan 410007,China
- Publication Type:Journal Article
- Keywords:
Thallium poisoning;
Acute poisoning;
Blood purification;
Sodium dimercaptosulfonate;
Treatment;
Clinical analysis
- From:
China Occupational Medicine
2018;45(03):347-354
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the clinical features,treatment methods and prognosis of acute thallium poisoning.METHODS: The clinical data of 2 cases of acute thallium poisoning were analyzed retrospectively to observe its clinical features,therapeutic effect of blood purification and sodium dimercaptosulfonate,and prognosis.RESULTS: The typical triads of clinical features of the two cases of acute thallium poisoning were gastroenteritis,polyneuropathy and alopecia.Before treatment,the blood thallium level was 200.6 and 712.7 μg/L and the urine thallium level was 5 206.4 and 11050.2 μg/24 h respectively.After the combined treatment using blood purification and sodium dimercaptosulfonate,the blood thallium decreased to 31.6 and 14.6 μg/L and the urine thallium decreased to 175.2 and 265.3 μg/24 h.The two patients had a good prognosis.The result of re-examination showed that blood thallium was 7.9 and 0.6 μg/L and the urine thallium was 31.5 and 5.5 μg/24 h respectively in 2 and 5 months later.CONCLUSION: The combined treatment using blood purification and sodium dimercaptosulfonate is effective for acute thallium poisoning therapy.
