Correlation between GADD45 mRNA expression and exposure dose in peripheral blood of radiation workers
10.11763/j.issn.2095-2619.2017.03.014
- Author:
Qia WANG
1
;
Weiji MAI
1
;
Wenjuan LIU
1
;
Jie SUN
1
;
Maosheng YAN
1
;
Aichu YANG
1
;
Qingsong CHEN
1
;
Yuhua YANG
1
Author Information
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment Guangzhou,Guangdong 510300,China
- Publication Type:Journal Article
- Keywords:
Radiation exposed workers;
GADD45;
Gene expression;
Personal dose;
Ionizing radiation
- From:
China Occupational Medicine
2017;44(03):318-321
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To analyze the growth arrest and DNA damage gene 45( GADD45) mRNA expression in peripheral blood of radiation workers,and its relationship with exposure dose. METHODS: Using a typical sampling method,97 radiation workers from a hospital of Guangdong were selected as radiation group,48 hospital administrative staff without exposure to radiation and other occupational hazard factors were selected as control group. The real-time quantitative polymerase chain reaction was used to detect GADD45 mRNA expression of two groups. With the use of thermoluminescence dosimetry,we detected and collected personal dose data of radiation group over the past year. RESULTS: The GADD45 mRNA relative expression of the radiation group was higher than that of the control group( P < 0. 01).There was no correlation between GADD45 mRNA relative expression and factors such as personal dose,sex,age,length of service,smoking,and alcohol drinking( P > 0. 05). CONCLUSION: The ionizing radiation can lead to up-regulation of GADD45 mRNA expression in peripheral blood of radiation workers,but there was no linear relationship between GADD45 mRNA expression and its personal dose.
