Preemptive analgesia using flurbiprofen combined with dexamethasone for whole lung lavage of pneumoconiosis patients
10.11763/j.issn.2095-2619.2017.03.007
- Author:
Zheng GONG
1
;
Jun LI
1
;
Yuling ZHONG
1
;
Chunjie LIAO
1
;
Li MA
1
;
Lei LI
1
Author Information
1. Department of Anesthesiology,the People's Hospital of Guangxi Autonomous Region Nanning,Guangxi 530021,China
- Publication Type:Journal Article
- Keywords:
Flurbiprofen axetil injection;
Dexamethasone;
Pneumoconiosis;
Whole lung lavage;
Preemptive analgesia;
Clinical observation
- From:
China Occupational Medicine
2017;44(03):281-284
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effect of flurbiprofen( FPA) combined with dexamethasone on preemptive analgesia for whole lung lavage in pneumoconiosis patients. METHODS: Ninety pneumoconiosis patients who underwent whole lung lavage under general analgesia were divided into three groups by random number table method: combine treatment group,FPA group and control group,30 cases in each group. Patients in combine treatment group were given 2 mg/kg body weight( bw) of flurbiprofen axetil injection and 10 mg of dexamethasone through intravenous injection before 2 hours of surgery. Patients in FPA group were given 2 mg/kg bw of FPA axetil injection intravenously. The control group was injected with 2 m L 0. 9% sodium chloride solution. Visual Analogue Scale( VAS) score,Bruggramann Comfort Scale( BCS) score,and adverse reaction of the three groups were recorded in 2,6,8,12 and 24 hours after operation. RESULTS: The postoperative VAS and BCS scores of combine treatment group at the 5 time points after operation were lower than that of control group and FPA group respectively( P < 0. 01). The VAS score between the 5 time points presented an decreasing tendency with the increase of time in the combine treatment group( P < 0. 05),and the BCS score presented an increasing tendency with the increase of time( P < 0. 05). The adverse reaction,such as nausea,vomiting dizziness and drowsiness,sore throat and skin itching in combine treatment group was lower than that of control group and FPA group 24 hours postoperatively( P < 0. 017). CONCLUSION: The therapy of FPA combined with dexamethasone on preemptive analgesia is a safe and effective method for reducing postoperative pain of whole lung lavage in pneumoconiosis patients.
