Detection of chloromethyl methyl ether and bis-chloromethyl ether in workplace air by gas chromatography
10.11763/j.issn.2095-2619.2017.01.014
- Author:
Weifeng RONG
1
;
Weijie LING
;
Jiawen HU
1
;
Jiaheng HE
1
;
Jingjing QIU
1
;
Ruibo MENG
1
;
Xiaolin RUAN
1
Author Information
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou,Guangdong 510300,China
- Publication Type:Journal Article
- Keywords:
Workplace;
Air;
Chloromethyl methyl ether;
Bis-chloromethyl ether;
Derivatizing reaction;
Gas chromatography
- From:
China Occupational Medicine
2017;44(01):75-79
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a methodology for simultaneous detection of chloromethyl methyl ether( CMME) and bis-chloromethyl ether( BCME) in workplace air by gas chromatography. METHODS: CMME and BCME in workplace air were collected with absorption solution which was also derivatization solution. The derivative products were extracted using n-hexane alkaline medium. The extracts were separated by capillary column and detected with electron capture detector.The quantification was performed by use of standard curves. RESULTS: The linearity ranges of CMME and BCME were2. 00-80. 00 and 1. 32-52. 80 ng,respectively. The correlation coefficients were both 0. 999 93. The minimum detectable concentrations were both 0. 030 μg / m3 and the minimum quantification concentrations were both 0. 100 μg / m3( 7. 50 L sample). The recovery rates were 99. 35%-101. 00% and 97. 99%-101. 70% respectively. The within-run relative standard deviations( RSD) were 2. 73%-4. 46% and 2. 61%-3. 82% respectively,and the between-run RSD were3. 10%-5. 50% and 3. 89%-5. 38% respectively. The sampling efficiencies were 92. 43%-96. 25% and 91. 43%-94. 03%respectively. The samples were stable at room temperature for at least 15 days. CONCLUSION: This method is suitable for simultaneous detection of CMME and BCME in workplace air.
