Four new dammarane-type triterpenoid saponins from Gynostemma longipes C.Y.Wu
10.16438/j.0513-4870.2021-0286
- VernacularTitle:长梗绞股蓝中的四个新达玛烷型三萜皂苷
- Author:
Qi LI
1
,
2
;
Xu PANG
3
;
Peng-xin LU
1
,
2
;
Jie ZHANG
3
;
Jun ZHANG
4
;
Dong-xiao SHI
4
;
Bai-ping MA
1
,
2
Author Information
1. Guangdong Pharmaceutical University, Guangzhou 510060, China
2. Institute of Radiation Medicine, Academy of Military Medical Science, Academy of Military Sciences, Beijing 100850, China
3. Institute of Radiation Medicine, Academy of Military Medical Science, Academy of Military Sciences, Beijing 100850, China
4. AnKang Chia Tai Pharmaceutical Co. Ltd., Ankang 725000, China
- Publication Type:Research Article
- Keywords:
Cucurbitaceae;
italic>Gynostemma longipes;
triterpenoid saponins;
isolation;
structural elucidation
- From:
Acta Pharmaceutica Sinica
2021;56(6):1670-1676
- CountryChina
- Language:Chinese
-
Abstract:
Dammarane-type triterpenoid saponins are regarded as the main active constituents of Gynostemma longipes C.Y.Wu. By using MCI and silica gel column chromatography, as well as preparative HPLC, we isolated four new dammarane-type triterpenoid saponins from the polar saponin fraction of G. longipes C.Y.Wu. Their structures were determined by comprehensive analyses of NMR and MS data and identified as (20S)-3β,20,21-trihydroxydammar-19-oxo-24-ene-3-O-{[α-L-rhamnopyranosyl(1→2)]-[β-D-xylopyranosyl(1→3)]-α-L-arabinopyranosyl}-21-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside (1), (20S)-3β,20,21-trihydroxydammar-24-ene-19-oxo-3-O-[α-L-rhamnopyranosyl(1→2)]-[β-D-xylopyranosyl(1→3)]-α-L-arabinopyranosyl-21-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (2), (20S)-3β,19,20,21-terahydroxydammar-24-ene-3-O-{[α-L-rhamnopyranosyl(1→2)]-[β-D-xylopyranosyl(1→3)]-α-L-arabinopyranosyl}-21-O-[β-D-glucopyranosyl(1→6)]-β-D-glucopyranoside (3), (20S)-3β,20,21-trihydroxydammar-24-ene-3-O-{[α-L-rhamnopyranosyl(1→2)]-[β-D-glucopyranosyl(1→3)]-β-D-glucopyranosyl}-21-O-[β-D-glucopyranosyl(1→6)]-β-D-glucopyranoside (4). Compounds 1-4 are new dammarane-type triterpenoid saponins which contain five glycosyl residues.
