Research progress of chemokines and their receptors in breast cancer
10.16438/j.0513-4870.2020-1996
- VernacularTitle:趋化因子及其受体在乳腺癌中的研究进展
- Author:
Wan-yu WANG
;
Xiao-xi LÜ
;
Zhuo-wei HU
;
Shan-shan LIU
- Publication Type:Research Article
- Keywords:
chemokine;
breast cancer;
signaling;
targeted therapy
- From:
Acta Pharmaceutica Sinica
2021;56(6):1521-1531
- CountryChina
- Language:Chinese
-
Abstract:
Chemokines are small cytokines with chemotactic activity, they are involved in regulating immune responses and inflammatory responses. In the development of tumors, chemokines are multi-functional mediators that not only affect the infiltration of immune cells into the tumor, but also have an important impact on tumor growth, angiogenesis, invasion, and metastasis. Besides, they are important targets of tumor therapy. Here we review chemokines involved in the regulation of signaling pathways, analyze the mechanism of chemokines in the development of breast cancer, summarize the chemokines targeted drugs for breast cancer in recent years and make a prospect about the role of chemokines in anti-breast cancer therapy.
