Research progress in mechanisms of idiosyncratic drug-induced liver injury mediated by inflammatory stress
10.16438/j.0513-4870.2020-1949
- VernacularTitle:炎症应激条件下特异质药物性肝损伤发生机制研究进展
- Author:
Xin JIANG
1
;
Dan LI
2
;
Lu-qin SI
1
;
Wei-jing GONG
3
,
4
;
San-lan WU
3
,
4
;
Jian-geng HUANG
1
Author Information
1. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Shenzhen University General Hospital, Shenzhen 518000, China
3. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
4. Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430022, China
- Publication Type:Research Article
- Keywords:
inflammatory stress;
idiosyncratic drug-induced liver injury;
lipopolysaccharide;
mechanism
- From:
Acta Pharmaceutica Sinica
2021;56(6):1544-1550
- CountryChina
- Language:Chinese
-
Abstract:
Idiosyncratic drug-induced liver injury (IDILI) is an unpredictable serious adverse drug reaction, which only occurs in a minority of special susceptible individuals. Although the mechanism of IDILI has not been fully understood, several hypotheses have been proposed to explain the action mode and specific mechanism of IDILI. Of these hypotheses, inflammatory stress hypothesis is one of the most important theories. Under the condition of inflammatory stress, drugs interact with inflammation and mediate the occurrence of IDILI through a variety of mechanisms, which can induce the production of inflammatory cytokines, activate coagulation system, affect the activity of metabolites, induce cholestasis, affect mitochondrial damage, and others. This review will summarize the main mechanisms and influencing factors of IDILI mediated by inflammatory stress, in order to provide a reference for preclinical drug development and basic research on drug-induced liver injury.
