The latest research progress of torpor occurrence mechanism
10.16438/j.0513-4870.2020-1751
- VernacularTitle:Torpor发生机制最新研究进展
- Author:
Zi-yu ZHU
;
Jian-wei JIANG
;
Jian-jun ZHANG
- Publication Type:Research Article
- Keywords:
torpor;
adcyap neuron;
leptin;
QRFP neuron;
sympathetic nervous system
- From:
Acta Pharmaceutica Sinica
2021;56(6):1532-1536
- CountryChina
- Language:Chinese
-
Abstract:
Torpor refers to a state in which the metabolic activity in the body of the living animal is greatly reduced during the period of reduced food supply, which is manifested as a substantial decrease in body temperature, metabolic level, and exercise level. Mammals have a strict body temperature regulation system to maintain a constant body temperature. When the energy supply is insufficient for a long time, some mammals will enter a hibernation state. Torpor is very similar to the hibernation state. The research on the mechanism of torpor state is of great significance in aerospace, military medicine and other fields. This review summarizes the specific mechanisms regulating the occurrence of torpor from four aspects: adenylate cyclase activating polypeptide (adcyap) neurons, leptin, pyroglutamylated RFamide peptide (QRFP) neurons, and sympathetic nervous system, aiming to provide ideas for further research on the mechanism of torpor.
