Progress in antitumor activity of baicalin
10.16438/j.0513-4870.2020-1642
- VernacularTitle:黄芩苷的抗肿瘤作用研究进展
- Author:
Bang-yan KONG
;
Li-bin WEI
;
Qing-long GUO
- Publication Type:Research Article
- Keywords:
baicalin;
tumor therapy;
cell cycle;
apoptosis;
invasion and metastasis
- From:
Acta Pharmaceutica Sinica
2021;56(6):1537-1543
- CountryChina
- Language:Chinese
-
Abstract:
Flavonoids baicalin is the main bioactive component extracted from Scutellaria baicalensis Georgi. Baicalin has high medicinal value and shows extensive pharmacological effects including antitumor, antibiosis, anti-inflammatory, antioxidation, neuro-protection, and significant potential in tumor treatment. Recent studies have shown that baicalin suppresses the growth of many kinds of human cancer. The underlying mechanisms include induction of apoptosis, induction of cell cycle arrest, inhibition of tumor metastasis, suppression of angiogenesis, and so on. This article reviewed the research progress of baicalin on its antitumor pharmacology and possible mechanisms at home and abroad, and provided the basis for its further research.
