A case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed.
- Author:
Hyun Soo CHOI
;
Chu Yeop HUH
;
Seung Bo KIM
- Publication Type:Case Report
- Keywords:
Topotecan;
Taxol-Cisplatin;
Advanced ovarian cancer
- MeSH:
Developed Countries;
Drug Therapy;
Female;
Humans;
Mortality;
Ovarian Neoplasms*;
Paclitaxel;
Platinum;
Topotecan*
- From:Korean Journal of Obstetrics and Gynecology
2000;43(5):914-917
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ovarian cancer has the highest mortality rate among gynecologic malignancies in developed countries. Most women present with advanced disease and require a combination of surgery and chemotherapy. One patient presented with recurrent ovarian cancer was initially treated with taxol and platinum-based compounds. Although response to these agents occurred, tumor progression was evident by elevated CA 125 levels and CT findings after a period of 4 months. This patient was then treated with topotecan and exhibited a response and stopped therapy. Topotecan exhibited activity in this patient with ovarian cancer resistent to both platinum and paclitaxel. We report a case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed.
