Research progress on the gene polymorphism of tacrolimus transporter in organ transplantation
10.3969/j.issn.1674-7445.2021.04.019
- VernacularTitle:他克莫司转运蛋白基因多态性在器官移植中的研究进展
- Author:
Hanshu ZHANG
1
;
Cangsang SONG
;
Yang ZHANG
;
Xingde LI
Author Information
1. Department of Pharmacy, the First Hospital of Kunming, Kunming 650051, China
- Publication Type:Research Article
- Keywords:
Tacrolimus (Tac);
Pharmacokinetics;
Blood drug concentration;
Gene polymorphism;
Organ transplantation;
Adenosine triphosphate-binding cassette (ABC) transporter;
Solute carrier (SLC) transporter;
Immunosuppressant
- From:
Organ Transplantation
2021;12(4):496-
- CountryChina
- Language:Chinese
-
Abstract:
Tacrolimus (Tac) is a commonly used immunosuppressant after organ transplantation, which has high immunosuppressive efficacy. However, the pharmacokinetics of Tac significantly differ among individuals, and gene polymorphism is the main influencing factor. In recent years, the gene polymorphism of drug transporter has become a novel research hotspot. Nevertheless, the effect of the gene polymorphism of transporter on Tac pharmacokinetics remains controversial. Consequently, the correlation between the gene polymorphism of transporter and Tac blood concentration plays a significant role in guiding Tac-based individualized immunosuppressive therapy. In this article, the research progresses on the gene polymorphism of adenosine triphosphate-binding cassette (ABC) transporter and solute carrier (SLC) transporter in organ transplantation was reviewed. The correlation between the gene polymorphism of transporter and Tac blood concentration was summarized, aiming to provide reference for Tac-based individualized therapy.
