The latest progress on JC virus infection after renal transplantation
10.3969/j.issn.1674-7445.2021.04.017
- VernacularTitle:肾移植术后JC病毒感染的最新进展
- Author:
Yu HE
1
;
Zhiyu OU
;
Yun MIAO
Author Information
1. Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China
- Publication Type:Research Article
- Keywords:
Renal transplantation;
JC virus;
BK virus;
JC virus-associated nephropathy (JCVAN);
BK virus-associated nephropathy (BKVAN);
Polyomavirus-associated nephropathy (PVAN);
Progressive multifocal leukoencephalopathy (PML)
- From:
Organ Transplantation
2021;12(4):484-
- CountryChina
- Language:Chinese
-
Abstract:
JC virus (JCV) is a member of polyomaviridae family that infects approximately 70% of the population worldwide. JCV constantly stays in a latent state after the primary infection. In immunosuppressed individuals, especially under the circumstances of low cellular immune function, JCV may be reactivated and lead to severe clinical manifestations. In recent years, the correlation between JCV and complications after renal transplantation has captivated widespread attention. JCV-associated nephropathy (JCVAN) has been reported. Here, latest research progresses on the epidemiology, molecular biology, in vivo infection process, JCV and complications after renal transplantation, and the relationship between JCV and BKV were reviewed, aiming to provide reference for the adjustment of immunosuppressive regimen following renal transplantation.
