Research status and prospect of basic application of islet organoid
10.3969/j.issn.1674-7445.2021.04.005
- VernacularTitle:胰岛类器官基础应用的研究现状与展望
- Author:
Lingling WU
1
;
Peng JIANG
;
Zhen WU
;
Wanli LI
;
Yuwei YANG
;
Hongjun GAO
Author Information
1. Guangxi University of Chinese Medicine, Nanning 530011, China
- Publication Type:Research Article
- Keywords:
Islet organoid;
Diabetes mellitus;
Human pluripotent stem cell (hPSC);
Embryonic stem cell (ESC);
Induced pluripotent stem cell (iPSC);
Organ transplantation;
Pancreatic and duodenal homeobox 1 (Pdx 1);
Neurogenin 3 (Ngn3)
- From:
Organ Transplantation
2021;12(4):397-
- CountryChina
- Language:Chinese
-
Abstract:
Organoids are tissue structures, generated from pluripotent stem cells and cultured in vitro, which form self-organize and recapitulate tissues with similar structure and function to the original organs. Organoids have similar appearance and function to the original tissues, and have been widely applied in basic research and clinical trial. At present, the organoids of liver, kidney, islet, brain, intestine and other organs have been successfully cultivated. The use of islet organoid is a hotspot in the field of organoid research. However, islet organoid is currently applied in basic research because rejection after organ transplantation and other issues remain unresolved. In this article, the origin, development and basic application of islet organoid were reviewed, aiming to provide reference for the transformation from basic research of islet organoid into clinical application as well as the treatment of diabetes mellitus.
