Attenuation of anti-measles antibody in the healthy population aged 1-14 years old in an urban district， Shanghai
10.19428/j.cnki.sjpm.2021.19949
- VernacularTitle:上海市某城区1～14岁人群麻疹疫苗抗体水平消减模型建立与分析
- Author:
Shu-hua LI
1
;
Cheng-xiao WANG
2
;
Xi-hong TANG
1
;
Xia GAO
1
;
Chun-zhu WU
2
;
Fan-di XIE
2
;
Yu CHEN
2
Author Information
1. Key Discipline of Epidemiology of Infectious Diseases，Jinshan District Center for Disease Control and Prevention， Shanghai 201599，China
2. Shanghai Fourth Peoples Hospital， Shanghai 20080，China
- Publication Type:Research Article
- Keywords:
measles;
healthy people;
antibody level;
fitting model
- From:
Shanghai Journal of Preventive Medicine
2021;33(5):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the level of anti-measles antibody in healthy population aged 1-14 years old in Shanghai， and project the risk of measles incidence in adult population in the future， which may provide evidence for enhancing the measles immunization strategy. Methods:A cross-sectional study was conducted to collect the serum of healthy people aged 1-14 years old in an urban district hospital in Shanghai. Serum concentration of anti-measles IgG antibody was examined by enzyme-linked immunosorbent assay （ELISA） and dynamics of IgG antibody was compared. Results:The prevalence of anti-measles antibody in healthy people aged 1-14 years old was determined to be 95.29%， and the antibody protection rate was 61.86%. There was no significant difference in the distribution of antibody between men and women （P>0.05）. However， there was statistical difference in the distribution of antibody among different age groups （P<0.05）， in which the antibody showed a decreasing trend with age， especially after the age of 10 years. The lowest prevalence of anti-measles antibody and protection rate were observed in the population aged 13-14 years old， which were 87.41% and 22.96%， respectively. The GMT was 2.667 1 （equal to the concentration of anti-measles IgG antibody being 464.62 mIU/mL）. According to the fitting model Ŷ
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=3.217-0.04X（R2=0.943，P<0.05）， the antibody protection rate was projected to decrease to zero in the population aged 19-20 years old， whereas the anti-measles antibody was to zero in the population aged 29-30 years old . Conclusion:As there is almost no natural infection of measles，the anti-measles antibody after measles vaccine immunization showed a linearly decreasing trend with age after measles immunization．It is recommended that people aged 10-15 years should be administered intensive immunization for prevention of adults measles，which could be incorporated into current measles immunization strategies.
