Advances in the research on mechanism of tumor metabolism regulated by c-Myc
10.11665/j.issn.1000-5048.20210316
- VernacularTitle:c-Myc调控肿瘤代谢作用机制的研究进展
- Author:
Yahui LIU
1
;
Lu GAO
;
Yajing WANG
;
Fang YAN
Author Information
1. 中国药科大学药物分析系
- Publication Type:Journal Article
- Keywords:
c-Myc;
antitumor;
glycolysis;
glutamine metabolism;
tricarboxylic acid cycle;
lipid metabolism;
nucleotide metabolism
- From:
Journal of China Pharmaceutical University
2021;52(3):379-386
- CountryChina
- Language:Chinese
-
Abstract:
The transcription factor c-Myc regulates the proliferation, differentiation, metabolism and other key processes of normal cells extensively.The unleashed MYC oncogene frequently produces abundant c-Myc protein, which directly regulates the gene expression of key metabolic enzymes, or tumor-related metabolic pathways by inhibiting microRNA, leading to abnormal metabolism characterized by heightened nutrients uptake, enhanced glycolysis and glutaminolysis, and elevated fatty acid and nucleotide synthesis.This paper briefly summarizes how c-Myc regulated metabolism on glycolysis, glutamine metabolism, tricarboxylic acid cycle, lipid metabolism and nucleotide synthesis in cancer cell,which provides some theoretical reference for the development of antitumor targets and drugs involving c-Myc.
