Interplay between non-coding RNA and insulin signaling pathway and its clinical application
10.11665/j.issn.1000-5048.20210303
- VernacularTitle:非编码RNA与胰岛素信号通路关系及其临床应用
- Author:
Yuhong LIU
1
;
Fangfang ZHANG
;
Jianxing LIU
;
Yue LIU
;
Yue YANG
;
Liang JIN
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
non-coding RNA;
insulin signaling pathway;
diabetes;
islet β cells
- From:
Journal of China Pharmaceutical University
2021;52(3):279-286
- CountryChina
- Language:Chinese
-
Abstract:
Non-coding RNA (ncRNA) is a type of RNA that has no or limited protein-coding ability. It mainly includes microRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA), transfer RNA (tRNA), PIWI-interacting RNA (piRNA), and small nucleolar RNA (snoRNA).At present, research has found that ncRNA plays a central role in regulating the function of pancreatic β cells, and that defects of insulin signaling is an important cause of diabetes.This article reviews the relationship between ncRNA and insulin signaling pathway in recent years, and discusses the possibility of ncRNA as a potential therapeutic target and clinical diagnostic marker for diabetes, hoping to provide some reference for the treatment and diagnosis of diabetes.
