Fish oil capsule supplementation in children with obesity reduced c-reactive protein and improved blood pressure
https://doi.org/10.31246/mjn-2019-0132
- Author:
I Gusti Lanang Sidiartha
1
;
Putu Diah Vedaswari
2
;
I Wayan Bikin Suryawan
3
Author Information
1. Pediatric Nutrition and Metabolic Disease Division, Department of Child Health, Faculty of Medicine, University of Udayana, Sanglah General Hospital, Bali, Indonesia
2. Department of Child Health, Faculty of Medicine, University of Udayana, Sanglah General Hospital, Bali, Indonesia
3. Department of Child Health, Wangaya Hospital, Bali, Indonesia
- Publication Type:Journal Article
- Keywords:
Fatty acid, inflammation, cytokine
- From:
Malaysian Journal of Nutrition
2020;26(No.3):453-460
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Excessive accumulation of body fat in obesity increases morbidities
such as hypertension and cardiovascular diseases. This study investigated the effect
of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation
on the level of high-sensitivity C-reactive protein (hs-CRP) and blood pressure
in children with obesity. Methods: Fifty obese children, aged 6-10 years, were
randomly assigned to the supplementation group (n=25) who received EPA and DHA
supplementation or to the placebo group (n=25) for eight weeks. The trial was done
in a single centre in Denpasar, Bali, Indonesia. Randomisation and allocation to the
trial group were done by a computer system. The primary analysis was comparing the
blood pressure and hs-CRP level between groups. Analysis of covariance (ANCOVA)
and multivariate analysis of covariance (MANCOVA) tests were done to compare the
differences between groups, with a p-value <0.05 considered as significant. Results:
A total of 44 children completed the study, 24 (54.5%) were males and 20 (45.5%)
were females. Initially, the systolic/diastolic blood pressure and hs-CRP level in
the supplementation and placebo groups were 109.5/72.7 mmHg and 3.5 mg/L,
107.9/68.4 mmHg and 2.8 mg/L, respectively. At the end, they were 106.3/67.7
mmHg and 1.7 mg/L, and 108.1/71.8 mmHg and 2.8 mg/L, respectively. Systolic-,
diastolic blood pressure and hs-CRP level were decreased by -2.6 mmHg (95%
CI: -6.9 to 1.6; p=0.220), -7.5 mmHg (95% CI: -12.4 to -2.6; p=0.004), and -1.15
mg/L (95% CI: -2.1 to -0.2; p=0.022), respectively. Conclusion: EPA and DHA
supplementation in obese children showed significant decrease in diastolic blood
pressure and hs-CRP level.
- Full text:4.2020my0514.pdf
