The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage Ⅰ-ⅢA by two different follow-up patterns: A multi-center, real-world study
- VernacularTitle:11 958 例Ⅰ~ⅢA 期非小细胞肺癌手术患者不同随访方式 5 年生存率比较的多中心真实世界研究
- Author:
Daqiang SUN
1
;
Pingyan CHEN
2
;
Lunxu LIU
3
;
LI Xiaofei
4
,
5
;
Jian HU
6
;
Lin XU
7
;
Xiangning FU
8
;
Yang LIU
9
,
10
;
Deruo LIU
11
;
Xun ZHANG
1
;
Jianxing HE
12
Author Information
1. Department of Thoracic Surgery of Tianjin Chest Hospital, Tianjin, 300051, P.R.China
2. Hainan Institute of Real World Data, Department of Biostatistics, Southern Medical University, Guangzhou, 510515, P.R.China
3. Department of Thoracic Surgery of West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
4. Department of Thoracic Surgery of Tangdu Hospital, Fourth Military Medical University, Xi&rsquo
5. an, 710038, P.R.China
6. Department of Thoracic Surgery of The First Hospital Affiliated to Medical College of Zhejiang University, Hangzhou, 310009, P.R.China
7. Department of Thoracic Surgery of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, 210009, P.R.China
8. Department of Thoracic Surgery of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430010, P.R.China
9. Department of Thoracic Surgery of Chinese People&rsquo
10. s Liberation Army General Hospital, Beijing, 100038, P.R.China
11. Department of Thoracic Surgery of China-Japan Friendship Hospital, Beijing, 100029, P.R.China
12. Department of Thoracic Surgery of The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, P.R.China
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
surgical resection;
follow-up pattern;
5-year survival rate;
real-world study
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2021;28(06):615-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the 5-year survival rates between two different follow-up patterns of postoperative stage Ⅰ-ⅢA non-small cell lung cancer (NSCLC) patients. Methods Pathological stage Ⅰ-ⅢA NSCLC 11 958 patients who underwent surgical resection and received follow-up within 6 months after initial diagnosis through telephone follow-up system were included in nine hospitals from July 2014 to July 2020. The patients were divided into two groups including a proactive follow-up group (n=3 825) and a passive follow-up group (n=8 133) according to the way of following-up. There were 6 939 males and 5 019 females aged 59.8±9.5 years. The Kaplan-Meier and Cox proportional hazards regression model were used. Results The median follow-up frequency was 8.0 times in the proactive follow-up group and 7.0 times in the passive follow-up group. The median call duration was 3.77 minutes in the proactive follow-up group and 3.58 minutes in the passive follow-up group. The 5-year survival rate was 81.8% and 74.2% (HR=0.60, 95CI 0.53-0.67, P<0.001) in the proactive follow-up group and the passive follow-up group, respectively. Multivariate analysis showed that follow-up pattern, age, gender and operation mode were independent prognostic factors, and the results were consistent in all subgroups stratified by clinical stages. Conclusion The proactive follow-up leads to better overall survival for resected stage Ⅰ-ⅢA NSCLC patients, especially in the stage ⅢA.
