Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis.

Zhiyao XU; Zhuha Zhou; Jing Zhang; Feichao Xuan; Mengjing Fan; Difan Zhou; Zhenyu Liuyang; Ximei MA; Yiyang Hong; Yihong Wang; Sherven Sharma; Qinghua Dong; Guanyu Wang

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Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis.

Author: Zhiyao XU ¹ ; Zhuha ZHOU ² ; Jing ZHANG ¹ ; Feichao XUAN ³ ; Mengjing FAN ¹ ; Difan ZHOU ³ ; Zhenyu LIUYANG ³ ; Ximei MA ³ ; Yiyang HONG ¹ ; Yihong WANG ⁴ ; Sherven SHARMA ⁵ ; Qinghua DONG ¹ ; Guanyu WANG ³
Author Information

1. Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
2. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
3. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
4. Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
5. David Geffen School of Medicine at UCLA, and the Veterans Affairs, Los Angeles, CA 90095, USA.
Publication Type:Journal Article
Keywords: AKT; ANOVA, One-way analysis of variance; BMI-1; CRC, colorectal cancer; CRCLM, colorectal cancer liver metastasis; Colorectal cancer; EMT, epithelial–mesenchymal transition; Epithelial–mesenchymal transition; GSK-3β; HDACi, histone deacetylase inhibitor; HE, hematoxylin and eosin; IHC, immunohistochemistry; LNM, lymph node metastasis; Liver metastasis; NaB, sodium butyrate; PBS, phosphate buffered solution; PcG, polycomb-group; Snail; Sodium butyrate; TCGA, Cancer Genome Atlas; qPCR, real time polymerase chain reaction
From: Acta Pharmaceutica Sinica B 2021;11(5):1274-1285
CountryChina
Language:English
Abstract: Liver is the most common metastatic site for colorectal cancer (CRC), there is no satisfied approach to treat CRC liver metastasis (CRCLM). Here, we investigated the role of a polycomb protein BMI-1 in CRCLM. Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage, invasion depth and right-sided primary tumor. Knockdown