New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors.
10.1016/j.apsb.2020.10.019
- Author:
Xu HU
1
,
2
;
Yan XIAO
3
;
Jianan SUN
1
,
2
;
Bao JI
1
,
2
;
Shanshan LUO
4
;
Bo WU
5
;
Chao ZHENG
6
;
Peng WANG
7
;
Fanxing XU
8
;
Keguang CHENG
9
,
10
;
Huiming HUA
1
,
2
;
Dahong LI
1
,
2
Author Information
1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education
2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
4. Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University, Nanjing 211166, China.
5. Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA.
6. PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
7. Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
8. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
9. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources
10. School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China.
- Publication Type:Review
- Keywords:
3-MST, 3-mercaptopyruvate sulfurtransferase;
AMPK, adenosine 5′-monophosphate-activated protein kinase;
Antitumor effect;
BCL-2, B-cell lymphoma-2;
BITC, benzyl isothiocyanate;
BRCA2, breast cancer 2;
CAT, cysteine aminotransferase;
CBS, cystathionine-β-synthase;
CDC25B, cell division cycle 25B;
CDK1, cyclin-dependent kinase 1;
CHK2, checkpoint kinase 2;
CSE, cystathionine-γ-lyase;
Cell proliferation;
DATS, diallyl trisulfide;
DR4, death receptor;
EMT, epithelial–mesenchymal transition;
ERK1/2, extracellular signal-regulated kinase;
ERU, erucin;
FOXM1, forkhead box protein M1;
GLUTs, glucose transporters;
H2S, hydrogen sulfide;
HDAC, histone deacetylase;
HEATR1, human HEAT repeat-containing protein 1;
HIF-1α, hypoxia inducible factor;
Hydrogen sulfide donor;
ITCs, isothiocyanates;
JNK, c-Jun N-terminal kinase;
KEAP1‒NRF2‒ARE, the recombinant protein 1-nuclear factor erythroid-2 related factor 2-antioxidant response element;
KRAS, kirsten rat sarcoma viral oncogene;
NF-κB, nuclear factor kappa B;
NO, nitric oxide;
OCT-4, octamer-binding transcription factor 4;
P16, multiple tumor suppressor 1;
PARP, poly(ADP-ribose)-polymerase;
PDGFRα, platelet-derived growth factor receptor;
PEITC, phenethyl isothiocyanate;
PI3K/AKT, phosphoinositide 3-kinase/v-AKT murine thymoma viral oncogene;
Pancreatic cancer;
RASAL2, RAS protein activator like 2;
ROS, reactive oxygen species;
RPL10, human ribosomal protein L10;
SFN, sulforaphane;
SHH, sonic hedgehog;
SMAD4, mothers against decapentaplegic homolog 4;
STAT-3, signal transducer and activator of transcription 3;
Signaling pathway;
Sulfur-containing compound;
TRAIL, The human tumor necrosis factor-related apoptosis-inducing ligand;
VEGF, vascular endothelial growth factor;
XIAP, X-linked inhibitor of apoptosis protein;
ZEB1, zinc finger E box-binding protein-1;
iNOS, inducible nitric oxide synthase
- From:
Acta Pharmaceutica Sinica B
2021;11(5):1148-1157
- CountryChina
- Language:English
-
Abstract:
As one of the most lethal diseases, pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities. Furthermore, pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found. Although combinations of new drugs, multimodal therapies, and adjuvants prolong survival, most patients still relapse after surgery and eventually die. Consequently, the search for more effective treatments for pancreatic cancer is highly relevant and justified. As a newly re-discovered mediator of gasotransmission, hydrogen sulfide (H
