Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS

Author: Fei XIA ¹ ; Zhongjian CHEN ² ; Quangang ZHU ² ; Jianping QI ¹ ; Xiaochun DONG ¹ ; Weili ZHAO ¹ ; Wei WU ¹ ; Yi LU ¹
Author Information

1. Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China.
2. Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
Publication Type:Journal Article
Keywords: Absorption; Aggregation-caused quenching; Caco-2; In vivo fate; Lipolysis; Lymph; SMEDDS; Trans-epithelial transport
From: Acta Pharmaceutica Sinica B 2021;11(4):1010-1020
CountryChina
Language:English
Abstract: Self-microemulsifying drug delivery systems (SMEDDSs) have recently returned to the limelight of academia and industry due to their enormous potential in oral delivery of biomacromolecules. However, information on gastrointestinal lipolysis and trans-epithelial transport of SMEDDS is rare. Aggregation-caused quenching (ACQ) fluorescent probes are utilized to visualize the