The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin.
10.1016/j.apsb.2021.02.015
- Author:
Baode SHEN
1
;
Chengying SHEN
1
;
Weifeng ZHU
2
;
Hailong YUAN
1
Author Information
1. Department of Pharmacy, Air Force Medical Center, PLA, Beijing 100142, China.
2. Key Lab of Modern Preparation of Traditional Chinese Medicine (TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
Biodistribution;
Biological fate;
Contribution;
Drug delivery;
Nanocrystals;
Oral bioavailability;
Pharmacokinetics;
Quercetin
- From:
Acta Pharmaceutica Sinica B
2021;11(4):978-988
- CountryChina
- Language:English
-
Abstract:
In this study, self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin hybrid nanocrystals (QT-HNCs) with diameter around 280 nm (QT-HNCs-280) and 550 nm (QT-HNCs-550) following oral and intravenous administration and the contribution of integral nanocrystals to oral bioavailability enhancement of QT was estimated by comparing the absolute exposure of integral QT-HNCs and total QT in the liver. Results showed that QT-HNCs could reside
