The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems.
10.1016/j.apsb.2020.11.020
- Author:
Canyu YANG
1
;
Bing HE
2
;
Wenbing DAI
2
;
Hua ZHANG
2
;
Ying ZHENG
3
;
Xueqing WANG
1
;
Qiang ZHANG
1
Author Information
1. Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Science, Peking University, Beijing 100191, China.
2. Beijing Key Laboratory of Molecular Pharmaceutics, New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
3. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
- Publication Type:Review
- Keywords:
5-FU, 5-fluorouracil;
ADC, antibody drug conjugates;
BBB, blood–brain barrier;
Biofate;
CAFs, cancer-associated fibroblasts;
CPT, camptothecin;
CSD, caveolin scaffolding domain;
CTB, cholera toxins B;
Cancer;
Caveolin-1;
Drug resistance;
ECM, extracellular matrix;
EGF, epidermal growth factor;
EGFR, epidermal growth factor receptor;
ER, endoplasmic reticulum;
ERK, extracellular regulated protein kinases;
FGF2, fibroblast growth factor 2;
GGT, γ-glutamyl transpeptidase;
GPI, glycosylphosphatidylinositol;
HER2, human epidermal growth factor receptor 2;
HMG-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A;
HSA, human serum albumin;
IBC, infiltrating breast cancer;
IR, insulin receptor;
MAPK, mitogen-activated protein kinase;
MDR, multidrug resistance;
MSV, multistage nanovectors;
NPs, nanoparticles;
Nano-drug delivery systems;
PC, prostate cancer;
PDGF, platelet-derived growth factor;
PFS, progression free survival;
ROS, reactive oxygen species;
SCLC, small cell lung cancer;
SV40, simian virus 40;
Transcytosis;
cell SMA, styrene maleic acid
- From:
Acta Pharmaceutica Sinica B
2021;11(4):961-977
- CountryChina
- Language:English
-
Abstract:
As one of the most important components of caveolae, caveolin-1 is involved in caveolae-mediated endocytosis and transcytosis pathways, and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal transduction. In recent years, the relationship between the expression level of caveolin-1 in the tumor microenvironment and the prognostic effect of tumor treatment and drug treatment resistance has also been widely explored. In addition, the interplay between caveolin-1 and nano-drugs is bidirectional. Caveolin-1 could determine the intracellular biofate of specific nano-drugs, preventing from lysosomal degradation, and facilitate them penetrate into deeper site of tumors by transcytosis; while some nanocarriers could also affect caveolin-1 levels in tumor cells, thereby changing certain biophysical function of cells. This article reviews the role of caveolin-1 in tumor prognosis, chemotherapeutic drug resistance, antibody drug sensitivity, and nano-drug delivery, providing a reference for the further application of caveolin-1 in nano-drug delivery systems.
