An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis.
10.1016/j.apsb.2020.10.016
- Author:
Xianyan QIN
1
;
Yingying XU
1
;
Xu ZHOU
1
;
Tao GONG
1
;
Zhi-Rong ZHANG
1
;
Yao FU
1
Author Information
1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Anti-TGFβ antibody;
BSA, bovine serum albumin;
CLT, celastrol;
Celastrol;
Controlled release;
Cy5.5-NHS, cyanine 5.5-N-hydroxysuccinimide;
DAPI, 4′,6-diamidino-2-phenylindole;
DEX, dexamethasone;
DiD, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindodicarbocyanineperchlorate;
ECM, extracellular matrix;
EDCI, carbodiimide hydrochloride;
ESR, equilibrium swelling ratio;
FITC, fluorescein isothiocyanate;
G", the loss modulus;
G', storage modulus;
HA, hyaluronic acid;
HASH, thiolated hyaluronic acid;
Hydrogel;
IL-1β, interleukin 1β;
IL-6, interleukin 6;
Inflammation;
Localized therapy;
MOD, mean optical density;
NHS, N-hydroxysuccinimide;
PDI, polydispersity index;
RIF, renal interstitial fibrosis;
RSR, real-time swelling ratio;
Renal fibrosis;
SD, standard deviation;
SEM, scanning electron microscopy;
TEM, transmission electron microscopy;
TGF-β1, transforming growth factor β1;
TNF-α, tumor necrosis factor α;
TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelling;
UUO, unilateral ureteral obstruction;
bis-F127-MA, bis-F127-methacrylate;
iNOS, nitric oxide synthase;
α-SMA, α-smooth muscle actin;
“Plum‒pudding” structure
- From:
Acta Pharmaceutica Sinica B
2021;11(3):835-847
- CountryChina
- Language:English
-
Abstract:
Localized delivery, comparing to systemic drug administration, offers a unique alternative to enhance efficacy, lower dosage, and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests. Herein, a localized drug delivery platform ("plum‒pudding" structure) with controlled release and long-acting features is developed through an injectable hydrogel ("pudding") crosslinked
